Sedentary Conduct May Enhance Threat of Dry Eye Illness

Jelle Vehof, MD, PhD

A brand new cross-sectional research from the Netherlands suggests elevated sedentary time could subsequently improve dry eye illness (DED) danger, even after adjusting for medical comorbidities.1

When excluding pc use-intensive sitting time from whole sitting time, the affiliation remained important between sedentary conduct and extremely symptomatic dry eye, however not for scientific prognosis of DED. Nonetheless, adequate bodily exercise attenuated the elevated danger of dry eye from sedentary conduct, based on the info.

“Display screen use, medical comorbidities, and adequate bodily exercise ought to, due to this fact, be thought-about as key confounding elements within the relationship between sedentary conduct and dry eye illness,” investigators wrote.1

The hyperlink between sedentary conduct and DED stays unclear, with each optimistic and damaging associations reported in earlier research.2 Within the present research, investigators led by Jelle Vehof, MD, PhD, Dutch Dry Eye Clinic, have been the primary to evaluate this relationship in a European inhabitants in addition to the primary to check if bodily exercise was an impact modifier of the affiliation.

Utilizing the population-based Lifelines cohort, a baseline evaluation (1A) was performed between 2007 and 2012, adopted by two questionnaires. A second evaluation (2A) was carried out between 2014 and 2017, with a follow-up questionnaire supplied between 2015 and 2019.

Standing of DED was assessed at 2A with the Ladies’s Well being Research (WHS) dry eye questionnaire, with the primary end result measure of the research being WHS-defined DED. Members indicated their sedentary conduct in whole every day sitting time utilizing the Marshall Sitting Questionnaire (MSQ) and their bodily exercise with the Quick Questionnaire to Assess Well being-Enhancing Bodily Exercise (SQUASH).

Outcomes present the prevalence of WHS-defined DED was 9.1% within the whole inhabitants of 48,418 individuals, with females being greater than twice as more likely to have DED than males (12.1% vs. 5.0%). Better sedentary conduct was linked to the next danger of WHS-defined DED in all analyses.

Every hour of every day sedentary conduct time elevated the percentages of getting WHS-defined DED by 1.5% (odds ratio [OR], 1.015 per hour/day; 95% confidence interval [CI], 1.005 – 1.024; P = .004). In the meantime, the info recommend sedentary conduct was linked to the next danger improve for extremely symptomatic dry eye (OR, 1.045) than for scientific prognosis (OR, 1.010).

After excluding sitting time from pc use-intensive domains, investigators discovered the affiliation between sedentary conduct and WHS-defined DED was not important (OR 1.007 per hour of sitting/day; 95% CI, 0.993 – 1.022; P = .31). Sedentary conduct with out pc use was considerably linked to extremely symptomatic dry eye in all fashions, however not with a scientific prognosis after changes for 48 medical comorbidities.

Relating to bodily exercise, the affiliation between sedentary conduct and DED was solely important for these with lower than WHO suggestions (OR, 1.022; 95% CI, 1.002 – 1.042; P = .027) and never in these assembly WHO suggestions (OR, 1.011; 95% CI, 0.999 – 1.023; P = .076).

Based mostly on this evaluation, bodily exercise could shield in opposition to DED, however investigators couldn’t verify the hyperlink, noting “causation can’t be assumed from this cross-sectional research.”1


1. Nguyen L, Magno MS, Utheim TP, Hammond CJ, Vehof J. The connection between sedentary conduct and dry eye illness. The Ocular Floor. 2023;28:11-17. doi:10.1016/j.jtos.2023.01.002

2. Hanyuda A, Sawada N, Uchino M, et al. Bodily inactivity, extended sedentary behaviors, and use of visible show terminals as potential danger elements for dry eye illness: JPHC-next research. The Ocular Floor. 2020;18(1):56-63. doi:10.1016/j.jtos.2019.09.007