Infants with acute ROP stay vulnerable to vision-threatening outcomes in later life

A brand new investigation into late vitreoretinal issues counsel infants with acute retinopathy of prematurity (ROP) stay at excessive danger of vision-threatening issues all through childhood and maturity.

In consequence, the investigative workforce led by Wei-Chi Wu, MD, PhD, Chang Gung Memorial Hospital in Taiwan, suggests the continuous follow-up of sufferers with ROP stays vital to detect danger and finally, higher affected person outcomes.

“When extreme issues, akin to retinal detachment or vitreous hemorrhage, well timed surgical intervention is important to make sure favorable visible outcomes in these sufferers,” wrote Wu and colleagues.

They got down to examine late vitreoretinal issues and visible outcomes in sufferers with regressed ROP with or with out prior remedy. The research was a part of a world, multicenter, noncomparative retrospective case collection. Within the research, a complete of 238 sufferers from 13 facilities worldwide who developed issues (retinal detachment, vitreous hemorrhage, or retinal break) ≥2 years after the decision of acute ROP have been analyzed by investigators.

Based on a affected person’s main prognosis, every participant was assigned to 1 of three teams, both retinal detachment, vitreous hemorrhage, or retinal break. Investigators documented and in contrast the common age at presentation, visible acuities, refractive error, axial size, gestational age, delivery weight, acute ROP classification, prior remedies for acute ROP, postoperative visible acuity (VA), and concomitant eye circumstances within the 3 teams.

The principle consequence measures have been medical options and visible outcomes of late vitreoretinal issues in sufferers with regressed ROP. A complete of 264 eyes of 238 sufferers have been included within the research.

Within the evaluation, the prior acute ROP standing was comparable among the many 3 teams. Nevertheless, the vitreous hemorrhage group had a better proportion of sufferers with sort 1 ROP (P = .03) and prior remedy (P <.001) than the opposite teams. Knowledge confirmed the common age at presentation was earlier within the retinal detachment (20.3 ± 15.5 years) and vitreous hemorrhage (21.4 ± 18.9 years) teams than within the retinal break group (31.9 ± 18.2 years; P < 0.001). The investigative workforce famous the retinal break group had one of the best presenting best-corrected visible acuity, adopted by the retinal detachment and vitreous hemorrhage teams (P <.001). Furthermore, the surgical intervention improved visible acuity in each the retinal detachment and vitreous hemorrhage teams (each P <.05). Results suggest the overall trend of visual acuity was the most favorable in the retinal break group, followed by that in the vitreous hemorrhage and retinal detachment groups. The findings further showed cicatricial changes in the fellow retina were observed in >90% of sufferers with unilateral involvement.

This text was revealed by our sister publication HCP Stay.


Hsu HT, Yu-Chuan Kang E, Blair MP, et. al Late vitreoretinal issues of regressed retinopathy of prematurity: Retinal Break, vitreous hemorrhage, and Retinal Detachment. Ophthalmology Retina. 2022;7(1):72-80. doi:10.1016/j.oret.2022.07.005